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DOI’s psychedelic effects are believed to come from its efficacy as an agonist at the 5-HT_2A, 5-HT_2B and 5-HT_2C receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain the subject of ongoing scientific inquiry.

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Buy 4 DOI 2 5 dimethoxy phenethylamine is a psychedelic drug and a substituted amphetamine. In neuroscience research, [¹²⁵I]-R-(−)-DOI is used as a radioligand and indicator of the presence of 5-HT_2A serotonin receptors.

Besides the longer duration, the trip tends to be more energetic than an LSD trip, with more body load and a different subjective visual experience.

The after effects include residual stimulation and difficulty sleeping, which, depending on the dose, may persist for days.

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